Blair Brettmann

Blair Brettmann

Postdoctoral Fellow

Contact Information

Office: (773) 702-7063

5735 South Ellis Avenue
Searle Laboratory 020
Chicago, IL 60637

Biographical Statement

Blair Brettmann received her B.S. in Chemical Engineering at the University of Texas at Austin in 2007. She received her Master's in Chemical Engineering Practice from MIT in 2009 following internships at GlaxoSmithKline (Upper Merion, PA) and Mawana Sugar Works (Mawana, India). Blair received her PhD in Chemical Engineering at MIT in 2012 working with the Novartis-MIT Center for Continuous Manufacturing under Prof. Bernhardt Trout. Her research focused on solid-state characterization and application of pharmaceutical formulations prepared by electrospinning. Following her PhD, Blair worked as a research engineer for Saint-Gobain Ceramics and Plastics for two years. While at Saint-Gobain she worked on polymer-based wet coatings and dispersions for various applications, including window films, glass fiber mats and architectural fabrics. Currently Blair is a postdoctoral researcher in the Institute for Molecular Engineering at the University of Chicago with Prof. Matthew Tirrell.


My research focuses on understanding phenomena occurring at the molecular level that influences stability and properties of complex formulations for a variety of applications. One project focuses on adapting current models of polyelectrolyte brushes to better reflect their behavior when exposed to multivalent ions. This is important for practical applications of polyelectrolyte brushes, as many water sources contain ions such as calcium and magnesium. I am also working on adapting the current understanding of polyelectrolyte complexes in water to dried polyelectrolyte complexes and investigating approaches to improve the mechanical properties and thus breadth of applicability of such materials.


  1. "Bridging contributions to polyelectrolyte brush collapse in multivalent salt solutions," Blair Kathryn Brettmann, Nicolas Laugel, Norman Hoffmann, Philip Pincus, Matthew Tirrell, Journal of Polymer Science Part A: Polymer Chemistry, 54, 284-291 (2016). [PDF]
  2. "Templated Nucleation of Acetaminophen on Spherical Excipient Agglomerates," J.L Quon, K. Chadwick, G.P.F. Wood, I. Sheu, B.K. Brettmann, A.S. Myerson, B.L. Trout, Langmuir, 29, 3292-3300 (2013). [PDF]
  3. "Electrospun Formulations Containing Crystalline Active Pharmaceutical Ingredients," B.K. Brettmann, K. Cheng, A.S. Myerson, B.L. Trout, Pharmaceutical Research, 30, 238-246 (2013). [PDF]
  4. "Free Surface Electrospinning of Fibers Containing Microparticles," B.K. Brettmann, S. Tsang, K.M. Forward, G.C. Rutledge, A.S. Myerson, B.L. Trout, Langmuir, 28, 9714-9721 (2012). [PDF]
  5. "Solid-state nuclear magnetic resonance study of the physical stability of electrospun drug and polymer solid solutions," B.K. Brettmann, A.S. Myerson, B.L. Trout, Journal of Pharmaceutical Sciences, 101, 2185-2193 (2012). [PDF]
  6. "Solid-state NMR characterization of high-loading solid solutions of API and excipients formed by electrospinning," B. Brettmann, E. Bell, A. Myerson, B. Trout, Journal of Pharmaceutical Sciences, 101, 1538-1545 (2012). [PDF]
  7. "Effects of Test Methods on Crevice Corrosion Repassivation Potential Measurements of Alloy 22," X. He, B. Brettmann, H. Jung, Corrosion, 65, 449-460 (2009). [PDF]
  8. "Design of Potent Amorphous Drug Nanoparticles for Rapid Generation of Highly Supersaturated Media," M.E. Matteucci, B.K. Brettmann, T.L Rogers, E.J. Elder, R.O. Williams, K.P. Johnston, Molecular Pharmaceutics, 4, 782-793 (2007). [PDF]
  9. "Coating Materials and Low Haze Heat Rejection Composites," B. Brettmann, A.Mafoud-Familia, C.H. Lai, R. Moerkerke, M. Kamath, U.S. Patent Application, 14/572432(2015). [PDF]
  10. "Composite bearings having a polyimide matrix," N. Mekhilef, B. Czarnecka, J.H. Peet, E. Malefant, B.K. Brettmann, H. Teng, U.S. Patent Application, 14/586569(2015). [PDF]
  11. "Electroprocessing of active pharmaceutical ingredients," B.K. Brettmann, A.S. Myerson, B.L. Trout, U.S. Patent Application, 13/832812 (2013). [PDF]
  12. "Layer processing for pharmaceuticals," B.L. Trout, T.A. Hatton, E. Chang, J.M. Evans, S. Mascia, W. Kim, R.R. Slaughter, Y. Du, H.H. Dhamankar, K.M. Forward, G.C. Rutledge, M. Wang, A.S. Myerson, B.K. Brettmann, N. Padhye, J-H. Chun, U.S. Patent Application, 13/458222 (2012). [PDF]