Jeff Ting

Jeffrey Ting

NIST-ChiMaD Postdoctoral Fellow

Contact Information

Office: (773) 702-7063
Email: jting1@uchicago.edu

5640 South Ellis Avenue
Eckhardt Research Center 108
Chicago, IL 60637

Biographical Statement

Jeff Ting received BS in Chemical Engineering at the University of Texas and worked under Dr. Grant C. Willson. Afterward, he received his PhD in Chemical Engineering from the University of Minnesota, where he worked with Profs. Frank Bates and Theresa Reineke on synthesizing tunable polymers as excipients for oral drug delivery. His graduate work aimed to explore fundamental structure-property relationships between solubilizing polymers and poorly water-soluble drugs using well-defined, modular polymer platforms for spray-dried dispersion applications. Jeff was a recipient of the L.E. and D.H. Scriven Fellowship, NSF Graduate Research Fellowship, and University of Minnesota Doctoral Dissertation Fellowship. His work was recognized by the first annual 2015 AIChE Pharmaceutical Discovery, Development and Manufacturing Student Award, and his 2015 publication in ACS Biomaterials Science & Engineering received a ACS Editors’ Choice distinction. Currently, Jeff is a postdoctoral researcher in Prof. Matt Tirrell’s group at the Institute for Molecular Engineering, where he is studying complex coacervation with multiblock assemblies.

Research

Polyelectrolyte complexes (PECs) can address broad societal needs as key ingredients in advanced biomaterials. These systems are assemblies of oppositely-charged polymers in aqueous solutions, which can be incorporated into various applications to judiciously design multifunctional nanomedicine carriers for tissue engineering, gene therapy, and theranostic probes. My current work involves studying the structural evolution, dynamics, and behavior of designer multiblock polymers as PECs in solution for new biomaterials applications. The goal of this work is to better understand how chain microstructures, properties, and hierarchical architectures affect the assembly mechanism and kinetics of entropy-driven PEC formation, which can range from PEC-core micelles to stimuli-responsive hydrogels. This work is being conducted under the Center for Hierarchical Materials Design (CHiMaD), a NIST Advanced Materials Center of Excellence program towards the goal of “Materials by Design” under President Obama’s 2011 Materials Genome Initiative (MGI).

Publications

  1. ”Polymer Day: Outreach Experiments for High School Students,” J. M. Ting, R. G. Ricarte, D. K. Schneiderman, Y. Jiang, S. A. Saba, M. A. Hillymer, F. S. Bates, T. M. Reineke, C. W. Macosko, T. P. Lodge, J. Chem. Educ. (2017).
  2. ”Direct observation of evolving nanostructures during aqueous dissolution of polymer/drug particles,” R. G. Ricarte, Z. Li, L. Johnson, J. M. Ting, T. M. Reineke, F. S. Bates, M. A. Hillmyer, T. P. Lodge, Macromolecules 50, 3143-3152 (2017). [PDF]
  3. ”High–throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals,” J. M. Ting, S. Tale, A. A. Purchel, S. D. Jones, L. Widanapathirana, Z. P. Tolstyka, G. Li, S. J. Guillaudeu, F. S. Bates, T. M. Reineke, ACS Cent. Sci. 2, 748–755 (2016). [PDF]
  4. ”Deconstructing HPMCAS: Excipient Design to Tailor Polymer–drug Interactions for Oral Drug Delivery,” J. M. Ting, T. S. Navale, S. D. Jones, F. S. Bates, T. M. Reineke, ACS Biomat. Sci. Eng. 1, 990–978 (2015). [PDF]
  5. ”Design of Tunable Multicomponent Polymers as Modular Vehicles to Deliver Highly Lipophilic Drugs,” J. M. Ting, T. S. Navale, F. S. Bates, T. M. Reineke, Macromolecules 47, 6554–6565 (2014). [PDF]
  6. ”Precise Compositional Control and Systematic Preparation of Multimonomeric Statistical Copolymers,” J. M. Ting, T. S. Navale, F. S. Bates, T. M. Reineke ACS Macro Lett., 2, 770–774 (2013). [PDF]

Patents

  1. Reineke, T. M.; Tale, S.; Bates, F. S.; Ting, J. M.; Widanapathirana, L.; Guillaudeu, S.; Li, G. “Copolymers as Excipients for Effective Solubilization of Poorly Water-Soluble Substances from Solid Mixtures” Patent Application No. 62/127,874, filed March 2015
  2. Navale, T. S.; Ting, J. M.; Bates, F. S.; Reineke, T. M. “Sugar containing, amphiphilic copolymers,” Patent Application No. 61/819,923, filed May 2013.
  3. Navale, T. S.; Ting, J. M.; Bates, F. S.; Reineke, T. M. “Sugar free, random copolymers made from at least three monomers,” Patent Application No. 61/819,928, filed May 2013.