Mat Schnorenberg

Mat Schnorenberg

Graduate Student

Contact Information

Office: (773) 702-7063

5640 South Ellis Avenue
Eckhardt Research Laboratory 108
Chicago, IL 60637

Biographical Statement

Mat Schnorenberg received his A.B. in Biomedical Engineering from Harvard University in 2014. He then came to the University of Chicago as an MD-PhD student. After completing his first year of medical school, he began his PhD in Molecular Engineering and is co-mentored by Professor Matthew Tirrell and Dr. James LaBelle. As an undergraduate, he worked with Dr. James D. Iglehart at Dana-Farber Cancer Institute in Boston, MA developing fluorescent, protein-based probes called "proteo-probes" for quantifying DNA damage and repair. In his undergraduate thesis, he developed an automated, quantitative, and high-throughput fluorescence microscopy system.


Mat's Ph.D. work is aiming at combining the LaBelle group's peptide-based cancer therapeutics and the Tirrell group's micellar drug delivery system to rationally design a modular drug delivery system that protects the drug on its journey in the bloodstream, helps it find a specific cellular target, and enhances its efficacy at its subcellular molecular target.


  1. "Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation," H. Acar, R. Samaeekia, M. R. Schnorenberg, D. K. Sasmal, J. Huang, M. V. Tirrell, J. L. LaBelle, Bioconjugate Chem., DOI: 10.1021/acs.bioconjchem.7b00364 (2017). [PDF]
  2. "Self-assembling peptide-based building blocks in medical applications," H. Acar, S. Srivastava, E. J. Chung, M. R. Schnorenberg, J. C. Barrett, J. L. LaBelle, M. Tirrell, Advanced Drug Delivery Reviews (2016). DOI: 10.1016/j.addr.2016.08.006 [PDF]
  3. "Monitoring repair of UV-induced 6-4-photoproducts with a purified DDB2 protein complex," M. Dreze, A. S. Calkins, J. Gálicza, D. J. Echelman, M. R. Schnorenberg, G. L. Fell, S. Iwai, D. E. Fisher, D. Szüts, J. D. Iglehart, J. B. Lazaro, PLoS ONE, 9, e85896 (2014). [PDF]